After exposing standard cultures of the ciliates to a soluble compound of nickel (NiCl 2.6H 2 O) at several selected concentrations close to the lethal limit for 24 h, the mortality rate was registered and the LC 50 values (with 95% confidence intervals) were calculated. These alloys are used in making metal coins and jewelry and in industry for making items such as valves and heat exchangers. Although lung lesions were seen only at the high dose in dogs in the Ambrose et al. We have also discussed nickel-induced genotoxicity, carcinogenicity, immunotoxicity and toxicity in various other metabolically active tissues. Over the past 15 yr there has been extensive development of biotic ligand models (BLMs) for various divalent metals, including nickel (Ni), that allow for the prediction of acute and chronic metal toxicity to aquatic organisms as a function of chemical parameters typical of freshwater systems. This may be a conservative value due to the lack of relevant acute inhalation toxicity data for workers. 2. Nickel (Ni) is a common pollutant found in aquatic environments and may be harmful at elevated concentrations. Lipid peroxidation may be the mechanism of acute nickel toxicity on target organs including the lungs (Sunderman 1987). INTRODUCTION. By measuring echene and ethane exhalation. (1976) study, lung lesions are fairly common in dogs. Pure nickel is a hard, silvery-white metal, which has properties that make it very desirable for combining with other metals to form mixtures called alloys. (6) Chronic Effects (Noncancer): Detecting Nickel Toxicity. When investigating possible nickel toxicity, we first perform a hair mineral analysis. The soluble compounds, such as nickel acetate, were the most toxic, and the insoluble forms, such as nickel powder, were the least toxic. Knight et al. Another great method for detecting nickel is to perform a Urine Toxic and Essential Elements Test. The acute toxicity of nickel to 12 species of freshwater ciliates was examined in laboratory tests. Some of the metals that nickel can be alloyed with are iron, copper, chromium, and zinc. (1986) found that lipid Acute animal tests in rats have shown nickel compounds to exhibit acute toxicity values ranging from low to high. Increasing salinity has been shown to decrease the bioavailability and toxicity of other metals to aquatic organisms. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above. In the present study, acute Ni toxicity experiments (96-h) were conduct … In this review, we address the acute, subchronic and chronic nickel toxicities in both human and experimental animals. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. Acute Nickel Toxicity i Plating Workers n Nickel concentrations in serum and urine specimens from the control electroplating workers (group C) are comparable to those previously observed in other nickel-plating operations [Bernacki et al., 1978, 1980; Tola et al., 19791. Revised IDLH: 10 mg Ni/m 3 Basis for revised IDLH: The revised IDLH for nickel compounds is 10 mg Ni/m 3 based on acute inhalation toxicity data in animals [NDRC 1943]. Flow-through toxicity tests were conducted on common freshwater fishes: rainbow trout (Oncorhynchus mykiss), three-spined stickleback (Gasterosteus aculeatus), roach (Rutilus rutilus), perch (Perca fluviatilis) and dace (Leuciscus leuciscus), to estimate their sensitivity to acute toxicity of nickel. At the high dose in dogs heat exchangers ) study, lung were! 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